Gene Copy-Number Alterations: A Cost-Benefit Analysis
نویسندگان
چکیده
منابع مشابه
Gene Copy-Number Alterations: A Cost-Benefit Analysis
Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss the costs and benefits of DNA copy-number alterations. Changes in DNA copy number are largely detrimental. Amplifications or deletions of specific genes can elicit discrete...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.11.043